First asymmetric oxidation of tertiary amines by cyclohexanone monooxygenase

被引：43

作者：

Ottolina, G

Bianchi, S

Belloni, B

Carrea, G

Danieli, B

机构：

[1] CNR, Ist Biocatalisi & Riconoscimento Mol, I-20131 Milan, Italy

[2] CNR, Dipartimento Chim Organ & Ind, Ctr Studio Sostanze Organ Nat, I-20133 Milan, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 48期

关键词：

amines; enzymes; enzyme reactions; N-oxides; stereoselection;

D O I：

10.1016/S0040-4039(99)01780-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclohexanone monooxygenase catalyzes the asymmetric oxidation of some tertiary amines to amine N-oxides. The structure of the amine markedly influences the enantiomeric excess of products. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8483 / 8486

页数：4

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