Peripheral oxygen extraction in patients with malignant obstructive jaundice

被引：11

作者：

Junejo, M. A. ^{[1
]}

Siriwardena, A. K. ^{[1
]}

Parker, M. J. ^{[2
]}

机构：

[1] Manchester Royal Infirm, Hepatobiliary Surg Unit, Manchester M13 9WL, Lancs, England

[2] Manchester Royal Infirm, Manchester M13 9WL, Lancs, England

来源：

ANAESTHESIA | 2014年 / 69卷 / 01期

关键词：

INTERNAL BILIARY DRAINAGE; CHRONIC HEART-FAILURE; ELDERLY-PATIENTS; CARDIAC-FAILURE; EXERCISE; CYTOKINES; SURGERY; ENDOTOXIN; TRIAL;

D O I：

10.1111/anae.12478

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Malignant obstructive jaundice is associated with poor aerobic capacity. We measured oxygen consumption and oxygen extraction (arterial-venous oxygen content) in the legs of nine patients during cardiopulmonary exercise testing before pancreaticoduodenectomy. The median (IQR [range]) peak oxygen consumption was 67 (49-77 [32-84])% of predicted. Normal patterns of oxygen extraction were seen with increasing power towards lactate threshold. Near maximal oxygen extraction occurred at peak exercise. Femoral venous oxygen pressure and saturation exceeded baseline values whilst recovering from exercise. These findings suggest that peripheral oxygen extraction is normal during exercise in patients with malignant obstructive jaundice. The primary limitation in oxygen consumption is reduced oxygen delivery.

引用

页码：32 / 36

页数：5

共 17 条

[1]

[Anonymous], 2008, CHRON KIDN DIS EARL

[2]

BANNING AP, 1995, BRIT HEART J, V74, P27

[3]

A NEW METHOD FOR DETECTING ANAEROBIC THRESHOLD BY GAS-EXCHANGE [J].

BEAVER, WL ;

WASSERMAN, K ;

WHIPP, BJ .

JOURNAL OF APPLIED PHYSIOLOGY, 1986, 60 (06) :2020-2027

[4]

CYTOKINES, THE ACUTE-PHASE RESPONSE, AND RESTING ENERGY-EXPENDITURE IN CACHECTIC PATIENTS WITH PANCREATIC-CANCER [J].

FALCONER, JS ;

FEARON, KCH ;

PLESTER, CE ;

ROSS, JA ;

CARTER, DC .

ANNALS OF SURGERY, 1994, 219 (04) :325-331

[5]

Near-maximal fractional oxygen extraction by active skeletal muscle in patients with chronic heart failure [J].

Katz, SD ;

Maskin, C ;

Jondeau, G ;

Cocke, T ;

Berkowitz, R ;

LeJemtel, T .

JOURNAL OF APPLIED PHYSIOLOGY, 2000, 88 (06) :2138-2142

[6]

Endotoxin, cytokines, and endotoxin binding proteins in obstructive jaundice and after preoperative biliary drainage [J].

Kimmings, AN ;

van Deventer, SJH ;

Obertop, H ;

Rauws, EAJ ;

Huibregtse, K ;

Gouma, DJ .

GUT, 2000, 46 (05) :725-731

[7]

PREOPERATIVE EVALUATION OF CARDIAC-FAILURE AND ISCHEMIA IN ELDERLY PATIENTS BY CARDIOPULMONARY EXERCISE TESTING [J].

OLDER, P ;

SMITH, R ;

COURTNEY, P ;

HONE, R .

CHEST, 1993, 104 (03) :701-704

[8]

Cardiopulmonary exercise testing as a screening test for perioperative management of major surgery in the elderly [J].

Older, P ;

Hall, A ;

Hader, R .

CHEST, 1999, 116 (02) :355-362

[9]

EXPERIENCE WITH THE PREOPERATIVE INVASIVE MEASUREMENT OF HEMODYNAMIC, RESPIRATORY AND RENAL-FUNCTION IN 100 ELDERLY PATIENTS SCHEDULED FOR MAJOR ABDOMINAL-SURGERY [J].

OLDER, P ;

SMITH, R .

ANAESTHESIA AND INTENSIVE CARE, 1988, 16 (04) :389-395

[10]

Randomized clinical trial of the effect of intravenous fluid administration in patients with obstructive jaundice undergoing endoscopic drainage [J].

Padillo, FJ ;

Briceño, J ;

Cruz, A ;

Chicano, M ;

Naranjo, A ;

Vallejo, J ;

Martín-Malo, A ;

Pera-Madrazo, C ;

Sitges-Serra, A .

BRITISH JOURNAL OF SURGERY, 2005, 92 (01) :39-43

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