Individuals with autism spectrum disorder show normal responses to a fear potential startle paradigm

被引：49

作者：

Bernier, R ^{[1
]}

Dawson, G ^{[1
]}

Panagiotides, H ^{[1
]}

Webb, S ^{[1
]}

机构：

[1] Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2005年 / 35卷 / 05期

关键词：

autism spectrum disorders; amygdala; fear conditioning; potentiated startle;

D O I：

10.1007/s10803-005-0002-0

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The present study utilized a fear potentiated startle paradigm to examine amygdala function in individuals with autism spectrum disorder. Two competing hypotheses regarding amygdala dysfunction in autism have been proposed: (1) The amygdala is under-responsive, in which case it would be predicted that, in a fear potentiated startle experiment, individuals with autism would exhibit decreased fear conditioning and/or potentiation, and (2) The amygdala is over responsive, in which case an exaggerated potentiation of the startle response would be predicted. Fourteen adolescents and adults diagnosed with autism spectrum disorder and 14 age, gender, IQ, and anxiety level-matched typical adolescents and adults participated. Both participants with autism and typical participants potentiated the startle response following fear conditioning and no group differences in the latency or amplitude of the potentiated startle response were found. These results suggest that this aspect of amygdala function, namely fear conditioning and potentiation of the startle response, is intact in individuals with autism.

引用

页码：575 / 583

页数：9

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