Preparative separation of the diastereomers of methyl branched-chain phosphatidylcholines

被引：5

作者：

Bringezu, F ^{[1
]}

Dobner, B ^{[1
]}

Stritzel, R ^{[1
]}

Elsner, B ^{[1
]}

Nuhn, P ^{[1
]}

机构：

[1] UNIV HALLE WITTENBERG, INST PHARMAZEUT CHEM, D-06110 HALLE, GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 724卷 / 1-2期

关键词：

diastereomer separation; preparative chromatography; enantiomer separation; phosphatidylcholines; phospholipids; glycerols; glycerophosphocholines; fatty acids;

D O I：

10.1016/0021-9673(95)01014-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidylcholines with methyl branched-chain fatty acids linked to the sn-2-position of the glycerol backbone were prepared. Diastereomers were isolated if the methyl branching was at the 2-position of the fatty acids. The separation of the diastereomers was connected with the distance between the chiral centres, which was varied systematically. An increasing distance resulted in a decrease in the separation factors calculated from HPLC data. Starting the synthesis from chiral glycerol educts after separation, optically pure diastereomers of alpha-methyl branched chain phospholipids were obtained.

引用

页码：367 / 372

页数：6

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