The dissolution and complexing properties of ibuprofen and ketoprofen when mixed with N-methylglucamine

被引：24

作者：

de Villiers, MM ^{[1
]}

Liebenberg, W

Malan, SF

Gerber, JJ

机构：

[1] Potchefstroom Univ Christian Higher Educ, Res Inst Ind Pharm, ZA-2520 Potchefstroom, South Africa

[2] Potchefstroom Univ Christian Higher Educ, Sch Pharm, Dept Pharmaceut Chem, ZA-2520 Potchefstroom, South Africa

[3] Potchefstroom Univ Christian Higher Educ, Sch Pharm, Dept Pharmaceut Practice, ZA-2520 Potchefstroom, South Africa

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 08期

关键词：

D O I：

10.1081/DDC-100102259

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The objectives of this study were to improve the aqueous dissolution properties of the pool lv soluble nonsteroidal anti-inflammatory drugs ibuprofen and ketoprofen and to explore the use of N-methylglucamine (meglumine) to enhance the dissolution properties of poorly water-soluble drug powders. Changes in both differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD) results indicate that possibly complexes were produced between ibuprofen and N-methylglucamine. Similar changes were not observed for equivalent ketoprofen and N-methylglucamine mixtures. The results of solubility and dissolution studies in water at 25 degrees C and 37 degrees C showed that N-methylglucamine, in mixtures and coprecipitates, increased the solubility, intrinsic dissolution, and powder dissolution of ketoprofen and ibuprofen. N-Methylglucamine significantly improved the solubility and dissolution proper ties of both ibuprofen and ketoprofen even when DSC and XRD behavior did not indicate the formation of complexes.

引用

页码：967 / 972

页数：6

共 8 条

[1] DISSOLUTION RATES OF CORTICOSTEROIDS UTILIZING SUGAR GLASS DISPERSIONS [J].