A Health-Care System Perspective on Implementing Genomic Medicine: Pediatric Acute Lymphoblastic Leukemia as a Paradigm

被引：13

作者：

Evans, W. E. ^{[1
]}

Crews, K. R. ^{[1
]}

Pui, C-H ^{[2
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2013年 / 94卷 / 02期

基金：

美国国家卫生研究院;

关键词：

THIOPURINE S-METHYLTRANSFERASE; CLINICAL PHARMACOGENETICS; GENETIC ALTERATIONS; CATALYTIC-ACTIVITY; MERCAPTOPURINE; THERAPY; CHEMOTHERAPY; DEFICIENCY; PROGNOSIS; CODEINE;

D O I：

10.1038/clpt.2013.9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The promise of genomic medicine has received great attention over the past decade, projecting how genomics will soon guide the prevention, diagnosis, and treatment of human diseases. However, this evolution has been slower than forecast, even where evidence is often strong (e.g., pharmacogenomics). Reasons include the requirement for institutional resources and the need for the will to push beyond barriers impeding health-care changes. Here, we illustrate how genomics has been deployed to advance the treatment of childhood leukemia.

引用

页码：224 / 229

页数：6

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