The new metabolic treatments for sarcopenia

被引：35

作者：

Barillaro, Christian ^{[1
]}

Liperoti, Rosa ^{[1
]}

Martone, Anna Maria ^{[1
]}

Onder, Graziano ^{[1
]}

Landi, Francesco ^{[1
,2
]}

机构：

[1] Univ Cattolica Sacro Cuore, Policlin A Gemelli, Dept Geriatr, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Ctr Med Invecchiamento, Policlin A Gemelli, I-00168 Rome, Italy

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2013年 / 25卷 / 02期

关键词：

Sarcopenia; Nutrition; Muscle strength; Metabolic agents; HYDROXY-BETA-METHYLBUTYRATE; MUSCLE PROTEIN-SYNTHESIS; RANDOMIZED CONTROLLED-TRIAL; ESSENTIAL AMINO-ACIDS; VITAMIN-D SUPPLEMENTATION; BLIND CONTROLLED-TRIAL; TUMOR-NECROSIS-FACTOR; FAT-FREE MASS; SKELETAL-MUSCLE; BODY-COMPOSITION;

D O I：

10.1007/s40520-013-0030-0

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In terms of managing sarcopenia, many studies have shown that physical activity (in particular resistance exercise) and specific nutrition interventions such as protein and amino acids supplementation can improve muscle mass and strength in older adults. Moreover, several drugs have been suggested to have an impact on muscle outcomes, with various levels of scientific evidence. In the present paper we have reviewed the evidence regarding the effect of some new metabolic agents (vitamin D, leucine, beta-hydroxy beta- methylbutyrate, citrulline malate, ornithine, isoflavones) on sarcopenia and muscular outcomes in older adults. For each metabolic agent, we have also discussed the biological plausibility of the described effect.

引用

页码：119 / 127

页数：9

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