A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release

被引：158

作者：

Komlev, VS

Barinov, SM

Koplik, EV

机构：

[1] Russian Acad Sci, Inst Phys Chem Ceram, Moscow 119361, Russia

[2] Russian Acad Med Sci, Inst Normal Physiol, Moscow 109003, Russia

来源：

BIOMATERIALS | 2002年 / 23卷 / 16期

关键词：

hydroxyapatite; granules; drug delivery;

D O I：

10.1016/S0142-9612(02)00049-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study is aimed at the development of a method to fabricate Porous spherical hydroxyapatite (VIA) granules, which can be impregnated with a drug. These drug-loaded particles can be used as a system for targeted and time-controlled drug delivery, e.g. in bone Surgery. The method to produce Porous granules is based oil liquids immiscibility effect. A suspension of' HA powder in aqueous solution of gelatin and oil as a dispersion media were Used. By stirring file mixtures of these immiscible liquids, granules of 50-2000 mum diameter can easily be produced. Dependence of' the granules characteristics on the preparation route was studied. hi vivo experiments were performed to simulate drug release kinetics from the granules to the blood of rats. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3449 / 3454

页数：6

共 19 条

[1]

Aoki H., 1991, SCI MED APPL HYDROXY, P179

[2]

AVRAMENKO AV, 1999, THES CAND PHARM SCI, P15

[3] Effect of liposome albumin coatings on ferric ion retention and release from chitosan beads [J].