Liquified chitosan-alginate multilayer capsules incorporating poly(L-lactic acid) microparticles as cell carriers

被引:53
作者
Correia, Clara R.
Sher, Praveen
Reis, Rui L.
Mano, Joao F. [1 ]
机构
[1] 3Bs Res Grp Biomat Biodegradables & Biomimet, P-4806909 Taipas, Guimaraes, Portugal
基金
欧盟第七框架计划;
关键词
HOLLOW SPHERES; MICROCAPSULES; MICROSPHERES; DELIVERY; FILMS;
D O I
10.1039/c2sm26784e
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070305 [高分子化学与物理];
摘要
We report the development of liquified multilayer hierarchical capsules capable of providing cell adhesion sites to the encapsulated cells. The proof of principle is demonstrated with the example of a chitosan-alginate shell via layer-by-layer assembly, encapsulating cells adhered to the functionalized surface of poly(L-lactic acid) microparticles.
引用
收藏
页码:2125 / 2130
页数:6
相关论文
共 33 条
[1]
Water dispersible pH-responsive chitosan nanogels modified with biocompatible crosslinking-agents [J].
Arteche Pujana, Maite ;
Perez-Alvarez, Leyre ;
Cesteros Iturbe, L. Carlos ;
Katime, Issa .
POLYMER, 2012, 53 (15) :3107-3116
[2]
SOLVENT SELECTION IN THE PREPARATION OF POLY(DL-LACTIDE) MICROSPHERES PREPARED BY THE SOLVENT EVAPORATION METHOD [J].
BODMEIER, R ;
MCGINITY, JW .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, 43 (1-2) :179-186
[3]
EFFECT OF CAPSULE PERMEABILITY ON GROWTH OF CHO CELLS IN EUDRAGIT-RL MICROCAPSULES - USE OF FITC-DEXTRAN AS A MARKER OF CAPSULE QUALITY [J].
BROUGHTON, RL ;
SEFTON, MV .
BIOMATERIALS, 1989, 10 (07) :462-465
[4]
Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating [J].
Caruso, F ;
Caruso, RA ;
Möhwald, H .
SCIENCE, 1998, 282 (5391) :1111-1114
[5]
DELIVERY OF RECOMBINANT GENE-PRODUCTS WITH MICROENCAPSULATED CELLS IN-VIVO [J].
CHANG, PL ;
SHEN, N ;
WESTCOTT, AJ .
HUMAN GENE THERAPY, 1993, 4 (04) :433-440
[6]
Liquefied Capsules Coated with Multilayered Polyelectrolyte Films for Cell Immobilization [J].
Costa, Nazua L. ;
Sher, Praveen ;
Mano, Joao F. .
ADVANCED ENGINEERING MATERIALS, 2011, 13 (06) :B218-B224
[7]
Layer-by-Layer Assembly of Chitosan and Recombinant Biopolymers into Biomimetic Coatings with Multiple Stimuli-Responsive Properties [J].
Costa, Rui R. ;
Custodio, Catarina A. ;
Arias, Francisco J. ;
Rodriguez-Cabello, Jose C. ;
Mano, Joao F. .
SMALL, 2011, 7 (18) :2640-2649
[8]
The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility [J].
Dash, Biraja C. ;
Rethore, Gildas ;
Monaghan, Michael ;
Fitzgerald, Kathleen ;
Gallagher, William ;
Pandit, Abhay .
BIOMATERIALS, 2010, 31 (32) :8188-8197
[9]
De Geest B. G., 2012, ANGEW CHEM, V124, P3928
[10]
BUILDUP OF ULTRATHIN MULTILAYER FILMS BY A SELF-ASSEMBLY PROCESS .1. CONSECUTIVE ADSORPTION OF ANIONIC AND CATIONIC BIPOLAR AMPHIPHILES ON CHARGED SURFACES [J].
DECHER, G ;
HONG, JD .
MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA, 1991, 46 :321-327