Molecular modeling of saccharides, part 20 -: Guest-induced conformational change in a flexible host:: mono-altro-β-cyclodextrin

被引:60
作者
Fujita, K
Chen, WH
Yuan, DQ
Nogami, Y
Koga, T
Fujioka, T
Mihashi, K
Immel, S
Lichtenthaler, FW
机构
[1] Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528131, Japan
[2] Daiichi Coll Pharmaceut Sci, Minami Ku, Fukuoka 815, Japan
[3] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 8140180, Japan
[4] Tech Univ Darmstadt, Inst Organ Chem, D-64287 Darmstadt, Germany
关键词
D O I
10.1016/S0957-4166(99)00127-5
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Mono-altro-beta-cyclodextrin 1, a beta-cyclodextrin with one of the seven glucose units being configurationally changed to an altrose, is shown to be a flexible host undergoing a distinct conformational change within its altropyranose geometry upon intracavity inclusion of adamantanecarboxylate, thus representing an induced-fit model of binding rather than one following the rigid lock-and-key type pattern. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1689 / 1696
页数:8
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