Tigecycline in carbapenem-resistant Acinetobacter baumannii bacteraemia: Susceptibility and clinical outcome

被引：33

作者：

Kim, Nak-Hyun ^{[1
]}

Hwang, Jeong-Hwan ^{[1
]}

Song, Kyoung-Ho ^{[1
]}

Choe, Pyoeng Gyun ^{[1
]}

Kim, Eu Suk ^{[1
]}

Park, Sang-Won ^{[1
]}

Kim, Hong Bin ^{[1
]}

Kim, Nam Joong ^{[1
]}

Park, Wan Beom ^{[1
]}

Oh, Myoung-Don ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Internal Med, 101 Daehak Ro, Seoul, South Korea

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2013年 / 45卷 / 04期

关键词：

Carbapenem resistance; Acinetobacter baumannii; bacteraemia; tigecycline; MICROBIOLOGICAL OUTCOMES; SERIOUS INFECTIONS; SEVERE SEPSIS; SEPTIC SHOCK; EPIDEMIOLOGY; PNEUMONIA;

D O I：

10.3109/00365548.2012.732705

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Although tigecycline is considered one of the few therapeutic options for carbapenem-resistant Acinetobacter baumannii (CRAB) bacteraemia, its role in the treatment of CRAB bacteraemia remains unclear. We describe the clinical outcomes of 9 patients who received tigecycline for CRAB bacteraemia. Although all CRAB blood isolates were susceptible to tigecycline, 5 (56%) deaths were related to CRAB bacteraemia and 1 case of breakthrough CRAB bacteraemia was observed during tigecycline therapy. Clinical outcomes of tigecycline therapy may be poor in patients with tigecycline-susceptible CRAB bacteraemia, although multiple factors including delayed treatment could contribute to the poor outcomes.

引用

页码：315 / 319

页数：5

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