The role of TLR4 in the pathogenesis of indirect acute lung injury

被引：50

作者：

Hu, Rong ^{[1
]}

Xu, Hui ^{[1
]}

Jiang, Hong ^{[1
]}

Zhang, Ying ^{[1
]}

Sun, Yu ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Anaesthet, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2013年 / 18卷

基金：

中国国家自然科学基金;

关键词：

TLR4; IALI; LPS; Sepsis; Trauma Hemorrhage Shock; Ischemia-Reperfusion; Burn Injury; Review; TOLL-LIKE RECEPTOR-4; DOMAIN-CONTAINING ADAPTER; NF-KAPPA-B; PATTERN-RECOGNITION RECEPTORS; RESPIRATORY-DISTRESS-SYNDROME; IFN-BETA; INFLAMMATORY RESPONSE; EPITHELIAL-CELLS; NEUTROPHIL RECRUITMENT; SYSTEMIC INFLAMMATION;

D O I：

10.2741/4176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Indirect acute lung injury (IALI) manifests as rapid-onset respiratory failure following secondary clinical events to the parenchyma or lung vasculature, such as hemorrhage shock, extra-pulmonary sepsis, trauma, ischemia-reperfusion, and burn injury. Accumulating evidence demonstrates the pivotal role of pattern recognition receptors (PRRs) in the innate immune system of lung diseases. Toll like receptor 4 (TLR4), one of the well characterized PRRs, recognizes not only the lipopolysaccharide (LPS) of Gram-negative bacteria, but also the endogenous ligands in IALI. In this review, we summarize a variety of reports concerning the role of TLR4 and IALI pathogenesis.

引用

收藏

页码：1244 / 1255

页数：12

相关论文

共 102 条

[1]

Neutrophils and acute lung injury [J].

Abraham, E .

CRITICAL CARE MEDICINE, 2003, 31 (04) :S195-S199

[2]

Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[3]

Endothelium-derived toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs [J].

Andonegui, G ;

Bonder, CS ;

Green, F ;

Mullaly, SC ;

Zbytnuik, L ;

Raharjo, E ;

Kubes, P .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (07) :1011-1020

[4]

Novel signal transduction pathway utilized by extracellular HSP70 -: Role of Toll-like receptor (TLR) 2 AND TLR4 [J].

Asea, A ;

Rehli, M ;

Kabingu, E ;

Boch, JA ;

Baré, O ;

Auron, PE ;

Stevenson, MA ;

Calderwood, SK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (17) :15028-15034

[5]

Shock-induced neutrophil mediated priming for acute lung injury in mice - Divergent effects of TLR-4 and TLR-4/FasL deficiency [J].

Ayala, A ;

Chung, CS ;

Lomas, JL ;

Song, GY ;

Doughty, LA ;

Gregory, SH ;

Cioffi, WG ;

LeBlanc, BW ;

Reichner, J ;

Simms, HH ;

Grutkoski, PS .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (06) :2283-2294

[6]

E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury [J].

Bachmaier, Kurt ;

Toya, Sophie ;

Gao, Xiaopei ;

Triantafillou, Thomas ;

Garrean, Sean ;

Park, Gye Young ;

Frey, Randall S. ;

Vogel, Stephen ;

Minshall, Richard ;

Christman, John W. ;

Tiruppathi, Chinnaswamy ;

Malik, Asrar B. .

NATURE MEDICINE, 2007, 13 (08) :920-926

[7]

Hemorrhage-induced acute lung injury is TLR-4 dependent [J].

Barsness, KA ;

Arcaroli, J ;

Harken, AH ;

Abraham, E ;

Banerjee, A ;

Reznikov, L ;

McIntyre, RC .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 287 (03) :R592-R599

[8]

Innate immune defense on the attack in acute lung injury [J].

Baudouin, Simon .

CRITICAL CARE MEDICINE, 2010, 38 (01) :328-329

[9]

Role of Toll-like receptor 4 for the pathogenesis of acute lung injury in Gram-negative sepsis [J].

Baumgarten, G. ;

Knuefermann, P. ;

Wrigge, H. ;

Putensen, C. ;

Stapel, H. ;

Fink, K. ;

Meyer, R. ;

Hoeft, A. ;

Grohe, C. .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2006, 23 (12) :1041-1048

[10]

BEHMAOU Y, 2009, CRIT CARE MED, V37, P1724

← 1 2 3 4 5 6 7 8 9 10 →