Lung cancer in patients < 50 years of age -: The experience of an academic multidisciplinary program

Objective: To determine if the clinicopathologic features and survival of lung cancer patients < 50 years of age differ from those of older patients. Design: Retrospective review of patients with primary bronchogenic carcinoma diagnosed at a single, multidisciplinary cancer center, Setting: A National Cancer Institute-designated comprehensive cancer center in urban Detroit, MI. Patients: All patients with primary bronchogenic carcinoma evaluated in the Multidisciplinary Lung Cancer Clinic at the Barbara Ann Karmanos Cancer Institute between 1990 and 1993, Results: Of 1,012 patients with lung cancer, 126 (12.5%) were < 50 years old at diagnosis, with a median age of 44 years. The median age of the 886 patients greater than or equal to 50 years of age was 65 years, The gender (p = 0.08) and racial (p = 0.12) characteristics of the younger and older patient groups were not significantly different. More than 90% of patients in both groups were smokers, The incidence of adenocarcinoma was significantly higher in younger patients (48.4% vs 36.0%, p < 0.001), and early-stage disease was less frequently diagnosed in younger patients (4.8% vs 19.7%, p < 0.001), Younger patients were more likely than older patients to undergo treatment, including surgery and combined-modality therapy (p < 0.001), Median survival was 13 months in younger and 9 months in older patients, while overall survival was similar in younger and older patients (p = 0.13), Conclusions: Although younger patients with lung cancer present with more advanced-stage disease, their overall survival is similar to that of older patients, suggesting that lung cancer is not an inherently more aggressive disease in patients < 50 years of age.