Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

被引：936

作者：

Pearson, Kevin J. ^{[1
]}

Baur, Joseph A. ^{[21
,22
]}

Lewis, Kaitlyn N. ^{[1
]}

Peshkin, Leonid ^{[2
,3
]}

Price, Nathan L. ^{[1
,21
,22
]}

Labinskyy, Nazar ^{[4
]}

Swindell, William R. ^{[5
]}

Kamara, Davida ^{[1
]}

Minor, Robin K. ^{[1
]}

Perez, Evelyn ^{[1
]}

Jamieson, Hamish A. ^{[6
,7
]}

Zhang, Yongcling ^{[8
]}

Dunn, Stephen R. ^{[9
]}

Sharma, Kumar ^{[10
]}

Pleshko, Nancy ^{[11
]}

Woollett, Laura A. ^{[12
]}

Csiszar, Anna ^{[4
]}

Ikeno, Yuji ^{[13
,14
,15
]}

Le Couteur, David ^{[6
,7
]}

Elliott, Peter J. ^{[16
]}

Becker, Kevin G. ^{[8
]}

Navas, Placido ^{[17
,18
]}

Ingram, Donald K. ^{[19
]}

Wolf, Norman S. ^{[20
]}

Ungvari, Zoltan ^{[4
]}

Sinclair, David A. ^{[21
,22
]}

de Cabo, Rafael ^{[1
]}

机构：

[1] NIA, Lab Expt Gerontol, NIH, Baltimore, MD 21224 USA

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA 02115 USA

[4] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA

[5] Univ Michigan, Dept Pathol, Ann Arbor, MI 48103 USA

[6] Univ Sydney, Ctr Educ & Res Ageing, Concord, NSW 2139, Australia

[7] Univ Sydney, ANZAC Res Inst, Concord, NSW 2139, Australia

[8] NIA, Gene Express & Genom Unit, NIH, Baltimore, MD 21224 USA

[9] Thomas Jefferson Univ, Kimmel Canc Ctr, Nucl Acid Microarray Facil, Philadelphia, PA 19107 USA

[10] UCSD, La Jolla, CA 92014 USA

[11] Hosp Special Surg, New York, NY 10021 USA

[12] Univ Cincinnati, Med Ctr, Genome Res Ctr, Dept Pathol & Lab Med, Cincinnati, OH 45237 USA

[13] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA

[14] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78245 USA

[15] Audie Murphy VA Hosp STVHCS, Res Serv, San Antonio, TX 78245 USA

[16] Sirtris Pharmaceut Inc, Cambridge, MA 02139 USA

[17] Univ Pablo Olavide, CSIC, Inst Salud Carlos III, Ctr Andaluz Biol Desarrollo, Seville 41013, Spain

[18] Univ Pablo Olavide, CSIC, Inst Salud Carlos III, Ctr Invest Biomed & Red Enfermedades Raras, Seville 41013, Spain

[19] Louisiana State Univ System, Pennington Biomed Res Ctr, Nutr Neurosci & Aging Lab, Baton Rouge, LA 70808 USA

[20] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[21] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[22] Harvard Univ, Sch Med, Pau F Glenn Labs Biol Mech Aging, Boston, MA 02115 USA

来源：

CELL METABOLISM | 2008年 / 8卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2008.06.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A small molecule that safely mimics the ability of dietary restriction (DR) to delay, age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene, expression patterns in multiple tissues that parallel those induced by DR and every-othor-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.

引用

页码：157 / 168

页数：12

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