Directed differentiation of hippocampal stem/progenitor cells in the adult brain

被引：201

作者：

Jessberger, Sebastian ^{[1
,2
]}

Toni, Nicolas ^{[1
]}

Clemenson, Gregory D., Jr. ^{[1
]}

Ray, Jasodhara ^{[1
]}

Gage, Fred H. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Lab Genet, La Jolla, CA 92037 USA

[2] Swiss Fed Inst Technol ETH Zurich, Dept Biol, Inst Cell Biol, CH-8093 Zurich, Switzerland

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 08期

关键词：

D O I：

10.1038/nn.2148

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult neurogenesis is a lifelong feature of brain plasticity; however, the potency of adult neural stem/progenitor cells in vivo remains unclear. We found that retrovirus-mediated overexpression of a single gene, the bHLH transcription factor Ascl1, redirected the fate of the proliferating adult hippocampal stem/progenitor (AHP) progeny and lead to the exclusive generation of cells of the oligodendrocytic lineage at the expense of newborn neurons, demonstrating that AHPs in the adult mouse brain are not irrevocably specified in vivo. These data indicate that AHPs have substantial plasticity, which might have important implications for the potential use of endogenous AHPs in neurological disease.

引用

页码：888 / 893

页数：6

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