学术探索
学术期刊
新闻热点
数据分析
智能评审

Reprogramming of genome function through epigenetic inheritance

被引：309
作者：
Surani, MA
机构：
[1] Univ Cambridge, Wellcome CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England
[2] Univ Cambridge, Physiol Lab, Cambridge CB2 1QR, England
来源：
NATURE | 2001年 / 414卷 / 6859期
关键词：
D O I：
10.1038/35102186
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Most cells contain the same set of genes and yet they are extremely diverse in appearance and functions. It is the selective expression and repression of genes that determines the specific properties of individual cells. Nevertheless, even when fully differentiated, any cell can potentially be reprogrammed back to totipotency, which in turn results in re-differentiation of the full repertoire of adult cells from a single original cell of any kind. Mechanisms that regulate this exceptional genomic plasticity and the state of totipotency are being unravelled, and will enhance our ability to manipulate stem cells for therapeutic purposes.
引用
收藏
页码：122 / 128
页数：7
相关论文
共 79 条
  • [1] EPIGENETIC CONTROL OF TRANSGENE EXPRESSION AND IMPRINTING BY GENOTYPE-SPECIFIC MODIFIERS
    ALLEN, ND
    NORRIS, ML
    SURANI, MA
    [J]. CELL, 1990, 61 (05) : 853 - 861
  • [2] Arney KL, 2001, INT J DEV BIOL, V45, P533
  • [3] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    Bannister, AJ
    Zegerman, P
    Partridge, JF
    Miska, EA
    Thomas, JO
    Allshire, RC
    Kouzarides, T
    [J]. NATURE, 2001, 410 (6824) : 120 - 124
  • [4] Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
    Bell, AC
    Felsenfeld, G
    [J]. NATURE, 2000, 405 (6785) : 482 - 485
  • [5] Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle
    Betts, DH
    Bordignon, V
    Hill, JR
    Winger, Q
    Westhusin, ME
    Smith, LC
    King, WA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (03) : 1077 - 1082
  • [6] Methylation-induced repression - Belts, braces, and chromatin
    Bird, AP
    Wolffe, AP
    [J]. CELL, 1999, 99 (05) : 451 - 454
  • [7] THE ONTOGENY OF ALLELE-SPECIFIC METHYLATION ASSOCIATED WITH IMPRINTED GENES IN THE MOUSE
    BRANDEIS, M
    KAFRI, T
    ARIEL, M
    CHAILLET, JR
    MCCARREY, J
    RAZIN, A
    CEDAR, H
    [J]. EMBO JOURNAL, 1993, 12 (09) : 3669 - 3677
  • [8] Deletion of a silencer element in lgf2 results in loss of imprinting independent of H19
    Constância, M
    Dean, W
    Lopes, S
    Moore, T
    Kelsey, G
    Reik, W
    [J]. NATURE GENETICS, 2000, 26 (02) : 203 - 206
  • [9] PARENTAL IMPRINTING OF THE MOUSE INSULIN-LIKE GROWTH FACTOR-II GENE
    DECHIARA, TM
    ROBERTSON, EJ
    EFSTRATIADIS, A
    [J]. CELL, 1991, 64 (04) : 849 - 859
  • [10] Donohoe ME, 1999, MOL CELL BIOL, V19, P7237
12345678