Multimodal Magnetic Resonance Imaging Assessment of White Matter Aging Trajectories Over the Lifespan of Healthy Individuals

被引:132
作者
Bartzokis, George [1 ,2 ,5 ]
Lu, Po H. [3 ]
Heydari, Panthea [1 ]
Couvrette, Alexander [1 ]
Lee, Grace J. [3 ]
Kalashyan, Greta [1 ]
Freeman, Frank [1 ]
Grinstead, John W. [6 ]
Villablanca, Pablo [4 ]
Finn, J. Paul [4 ]
Mintz, Jim [7 ]
Alger, Jeffry R. [3 ]
Altshuler, Lori L. [1 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Lab Neuroimaging, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol, Los Angeles, CA 90095 USA
[5] Greater Los Angeles Vet Adm Healthcare Syst, Los Angeles, CA USA
[6] Siemens Healthcare, Portland, OR USA
[7] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA
基金
美国国家卫生研究院;
关键词
Aging; Alzheimer; axial diffusivity; cognition; degeneration; diffusion tensor imaging (DTI); development; fractional anisotropy; magnetic resonance imaging (MRI); myelin; oligodendrocytes; radial diffusivity; relaxation rate (R-2); white matter (WM); CUPRIZONE-INDUCED DEMYELINATION; MYELINATED NERVE-FIBERS; T2; RELAXATION-TIME; IN-VIVO; STRUCTURAL INTEGRITY; RADIAL DIFFUSIVITY; COGNITIVE FUNCTION; PROCESSING SPEED; CORPUS-CALLOSUM; VISUAL-CORTEX;
D O I
10.1016/j.biopsych.2012.07.010
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Background: Postmortem and volumetric imaging data suggest that brain myelination is a dynamic lifelong process that, in vulnerable late-myelinating regions, peaks in middle age. We examined whether known regional differences in axon size and age at myelination influence the timing and rates of development and degeneration/repair trajectories of white matter (WM) microstructure biomarkers. Methods: Healthy subjects (n = 171) 14-93 years of age were examined with transverse relaxation rate (R-2) and four diffusion tensor imaging measures (fractional anisotropy [FA] and radial, axial, and mean diffusivity [RD, AxD, MD, respectively]) of frontal lobe, genu, and splenium of the corpus callosum WM (FWM, GWM, and SWM, respectively). Results: Only R-2 reflected known levels of myelin content with high values in late-myelinating FWM and GWM regions and low ones in early-myelinating SWM. In FWM and GWM, all metrics except FA had significant quadratic components that peaked at different ages (R-2 < RD < MD < AxD), with FWM peaking later than GWM. Factor analysis revealed that, although they defined different factors, R-2 and RD were the metrics most closely associated with each other and differed from AxD, which entered into a third factor. Conclusions: The R-2 and RD trajectories were most dynamic in late-myelinating regions and reflect age-related differences in myelination, whereas AxD reflects axonal size and extra-axonal space. The FA and MD had limited specificity. The data suggest that the healthy adult brain undergoes continual change driven by development and repair processes devoted to creating and maintaining synchronous function among neural networks on which optimal cognition and behavior depend.
引用
收藏
页码:1026 / 1034
页数:9
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