Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior

被引：45

作者：

Barker, Jacqueline M. ^{[1
,2
]}

Torregrossa, Mary M. ^{[1
]}

Taylor, Jane R. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat,Connecticut Mental Hlth Ctr, Div Mol Psychiat,Ctr Genes & Behav,Abraham Ribico, New Haven, CT 06520 USA

[2] Yale Univ, Interdept Neurosci Program, New Haven, CT USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 10期

基金：

美国国家卫生研究院;

关键词：

INDUCTION; BDNF;

D O I：

10.1038/nn.3194

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The factors underlying vulnerability to alcoholism are largely unknown. We identified in rodents an innate endophenotype predicting individual risk for alcohol-related behaviors that was associated with decreased expression of the neuroplasticity-related polysialylated neural cell adhesion molecule (PSA-NCAM). Depletion of PSA-NCAM in the ventromedial prefrontal cortex was sufficient to render mice unable to extinguish alcohol seeking, indicating a causal role of naturally occurring variation. These data suggest a mechanism of aberrant prefrontal neuroplasticity that underlies enhanced propensity for inflexible addiction-related behavior.

引用

收藏

页码：1356 / 1358

页数：3

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