Distribution of felbamate in brain

被引：5

作者：

Cornford, EM

Truong, HVM

Sofia, RD

Kucharczyk, N

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,BRAIN RES INST,LOS ANGELES,CA 90024

[3] WALLACE LABS,CRANBURY,NJ

来源：

EPILEPSIA | 1996年 / 37卷 / 01期

关键词：

autoradiographic localization; dicarbamate anticonvulsant; CNS distribution;

D O I：

10.1111/j.1528-1157.1996.tb00505.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the distribution of felbamate (FBM) in rat brain using a brain imaging scanner to analyze thaw-mount autoradiographs. After intravenous injection of [C-14]FBM in rats, the autoradiographic distribution of isotope labeling patterns in brain was captured on x-ray film. Densitometric differences on the x-ray film were converted into color-code variations representing the different concentrations of FBM in regions of the brain. We demonstrated that relatively uniform concentrations of FBM were detected throughout the brain. In all brain regions examined, there were no specifically high or low concentrations of FBM. We conclude that the FBM distributes uniformly.

引用

页码：15 / 18

页数：4

共 15 条

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