A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation

被引：32

作者：

Persuh, M

Mandic-Mulec, I

Dubnau, D

机构：

[1] Publ Hlth Res Inst City New York Inc, New York, NY 10016 USA

[2] Univ Ljubljana, Ljubljana 1000, Slovenia

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 08期

关键词：

D O I：

10.1128/JB.184.8.2310-2313.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.

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页码：2310 / 2313

页数：4

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