Synthesis of 4'-aza analogues of 2',3'-dideoxythymidine by 1,3-dipolar cycloadditions of nitrones to 1-N-vinyl-thymine

被引:50
作者
Leggio, A [1 ]
Liguori, A [1 ]
Procopio, A [1 ]
Siciliano, C [1 ]
Sindona, G [1 ]
机构
[1] UNIV CALABRIA,DIPARTIMENTO CHIM,I-87030 RENDE,CS,ITALY
关键词
D O I
10.1016/0040-4039(95)02373-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The title compounds have been obtained by 1,3-dipolar cycloadditions of methylene nitromes, prepared in situ from suitably protected hydroxylamines, to 1-N-vinyl-thymine. The 4'-aza-2',3'-dideoxyerythrofuranoside(4), an analogue of 2',3'-dideoxythymidine, might exhibit antiviral activity.
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页码:1277 / 1280
页数:4
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