Synthesis of 4'-aza analogues of 2',3'-dideoxythymidine by 1,3-dipolar cycloadditions of nitrones to 1-N-vinyl-thymine

被引：50

作者：

Leggio, A ^{[1
]}

Liguori, A ^{[1
]}

Procopio, A ^{[1
]}

Siciliano, C ^{[1
]}

Sindona, G ^{[1
]}

机构：

[1] UNIV CALABRIA,DIPARTIMENTO CHIM,I-87030 RENDE,CS,ITALY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 08期

关键词：

D O I：

10.1016/0040-4039(95)02373-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds have been obtained by 1,3-dipolar cycloadditions of methylene nitromes, prepared in situ from suitably protected hydroxylamines, to 1-N-vinyl-thymine. The 4'-aza-2',3'-dideoxyerythrofuranoside(4), an analogue of 2',3'-dideoxythymidine, might exhibit antiviral activity.

引用

页码：1277 / 1280

页数：4

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