BigBrain: An Ultrahigh-Resolution 3D Human Brain Model

被引：532

作者：

Amunts, Katrin ^{[1
,2
,3
,4
]}

Lepage, Claude ^{[5
]}

Borgeat, Louis ^{[6
]}

Mohlberg, Hartmut ^{[1
,2
]}

Dickscheid, Timo ^{[1
,2
]}

Rousseau, Marc-Etienne ^{[5
]}

Bludau, Sebastian ^{[1
,2
]}

Bazin, Pierre-Louis ^{[7
]}

Lewis, Lindsay B. ^{[5
]}

Oros-Peusquens, Ana-Maria ^{[1
,2
]}

Shah, Nadim J. ^{[1
,2
]}

Lippert, Thomas ^{[8
]}

Zilles, Karl ^{[1
,2
,3
,4
]}

Evans, Alan C. ^{[5
]}

机构：

[1] Res Ctr Julich, Inst Neurosci & Med INM 1, INM 4, D-52425 Julich, Germany

[2] Julich Aachen Res Alliance JARA, Julich, Germany

[3] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Sect Struct Funct Brain Mapping, D-52074 Aachen, Germany

[4] Univ Dusseldorf, C&O Vogt Inst Brain Res, D-40001 Dusseldorf, Germany

[5] McGill Univ, Montreal Neurol Inst MNI, Montreal, PQ, Canada

[6] Natl Res Council Canada, Ottawa, ON, Canada

[7] Max Planck Inst Human Cognit & Brain Sci, D-04103 Leipzig, Germany

[8] Res Ctr Julich, Julich Supercomp Ctr JSC, D-52425 Julich, Germany

来源：

SCIENCE | 2013年 / 340卷 / 6139期

关键词：

HUMAN CEREBRAL-CORTEX; IN-VIVO; CORTICAL AREAS; PATTERNS; ATLASES; MRI; CYTOARCHITECTURE; SYSTEM; MONKEY; MAP;

D O I：

10.1126/science.1235381

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.

引用

页码：1472 / 1475

页数：4

共 38 条

[1] The Brain Activity Map [J].