A population based study of the epidemiology of Herpes Zoster and its complications

被引:137
作者
Weitzman, Dahlia [1 ]
Shavit, Oren [2 ]
Stein, Michal [2 ]
Cohen, Raanan [2 ]
Chodick, Gabriel [1 ,3 ]
Shalev, Varda [1 ,3 ]
机构
[1] Maccabi Healthcare Serv, Div Med, IL-68125 Tel Aviv, Israel
[2] MSD Israel, Hod Hasharon, Israel
[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
关键词
Herpes Zoster; Neuralgia; Postherpetic; Incidence; Risk factors; POSTHERPETIC NEURALGIA; RISK-FACTORS; UNITED-STATES; VARICELLA; VACCINE; INFECTION; SHINGLES; BURDEN; IMPACT; VIRUS;
D O I
10.1016/j.jinf.2013.06.016
中图分类号
R51 [传染病];
学科分类号
100201 [内科学];
摘要
Objectives: To assess the incidence of Herpes Zoster (HZ) and its complications in the Israeli general population and specifically in immune-compromised individuals, and to identify risk factors for developing HZ and post-herpetic neuralgia (PHN). Methods: A retrospective database search for newly diagnosed cases of HZ and of PHN during 2006-2010 was conducted using the comprehensive longitudinal database of Maccabi Health Services. Cox-proportional hazards models were used to assess associations between risk factors and HZ and PHN. Results: During 2006-2010 there were 28,977 newly diagnosed cases of HZ and 1508 newly diagnosed cases of PHN. Incidence density rate of HZ was 3.46 per 1000 person-years in the total population and 12.8 per 1000 person-years in immune-compromised patients. HZ and PHN incidence increased sharply with age. 12.4% and 3.1% of elderly HZ patients (>= 65 years) developed PHN or ophthalmic complications, respectively. In multivariable analyses, HZ and PHN were associated with female sex, higher socioeconomic status, diabetes mellitus, cancer history, and HIV treatment. Conclusions: Extrapolating to the entire Israeli population, we estimate over 24,000 new cases of HZ and 1250 new cases of PHN each year. Cost-effectiveness analysis should be performed to determine the threshold age for vaccination against HZ. (C) 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:463 / 469
页数:7
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