HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3

被引：31

作者：

Hotter, Dominik ^{[1
]}

Kirchhoff, Frank ^{[1
]}

Sauter, Daniel ^{[1
]}

机构：

[1] Univ Ulm, Med Ctr, Inst Mol Virol, D-89069 Ulm, Germany

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 12期

关键词：

DEPENDENT MECHANISM; RESTRICTION FACTOR; DOWN-MODULATION; PROTEIN; NEF; CELLS; RELEASE; DOMAIN; CD4; RESPONSES;

D O I：

10.1128/JVI.00526-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It has been reported that HIV-1 Vpu mediates the degradation of interferon regulatory factor 3 (IRF-3) to avoid innate immune sensing. Here, we show that Vpu does not deplete IRF-3 from transfected cell lines or HIV-1-infected primary cells. Furthermore, the Vpu-dependent suppression of beta interferon expression described in previous studies could be ascribed to inhibition of NF-kappa B activation. Thus, Vpu suppresses innate immune activation through inhibition of NF-kappa B rather than degradation of IRF-3.

引用

页码：7160 / 7165

页数：6

共 28 条

[1] Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3 [J].

Barro, M ;

Patton, JT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (11) :4114-4119

[2] THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VPU PROTEIN SPECIFICALLY BINDS TO THE CYTOPLASMIC DOMAIN OF CD4 - IMPLICATIONS FOR THE MECHANISM OF DEGRADATION [J].

BOUR, S ;

SCHUBERT, U ;

STREBEL, K .

JOURNAL OF VIROLOGY, 1995, 69 (03) :1510-1520

[3] Vpu-Deficient HIV Strains Stimulate Innate Immune Signaling Responses in Target Cells [J].

Doehle, Brian P. ;

Chang, Kristina ;

Fleming, Lamar ;

McNevin, John ;

Hladik, Florian ;

McElrath, M. Juliana ;

Gale, Michael, Jr. .

JOURNAL OF VIROLOGY, 2012, 86 (16) :8499-8506

[4] Vpu Mediates Depletion of Interferon Regulatory Factor 3 during HIV Infection by a Lysosome-Dependent Mechanism [J].

Doehle, Brian P. ;

Chang, Kristina ;

Rustagi, Arjun ;

McNevin, John ;

McElrath, M. Juliana ;

Gale, Michael, Jr. .

JOURNAL OF VIROLOGY, 2012, 86 (16) :8367-8374

[5] Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells [J].

Doehle, Brian P. ;

Hladik, Florian ;

McNevin, John P. ;

McElrath, M. Juliana ;

Gale, Michael, Jr. .

JOURNAL OF VIROLOGY, 2009, 83 (20) :10395-10405

[6] Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism [J].

Douglas, Janet L. ;

Viswanathan, Kasinath ;

McCarroll, Matthew N. ;

Gustin, Jean K. ;

Frueh, Klaus ;

Moses, Ashlee V. .

JOURNAL OF VIROLOGY, 2009, 83 (16) :7931-7947

[7] Innate Sensing of HIV-1 Assembly by Tetherin Induces NFκB-Dependent Proinflammatory Responses [J].

Galao, Rui Pedro ;

Le Tortorec, Anna ;

Pickering, Suzanne ;

Kueck, Tonya ;

Neil, Stuart J. D. .

CELL HOST & MICROBE, 2012, 12 (05) :633-644

[8] HIV-1 Antagonism of CD317 Is Species Specific and Involves Vpu-Mediated Proteasomal Degradation of the Restriction Factor [J].

Goffinet, Christine ;

Allespach, Ina ;

Homann, Stefanie ;

Tervo, Hanna-Mari ;

Habermann, Anja ;

Rupp, Daniel ;

Oberbremer, Lena ;

Kern, Christian ;

Tibroni, Nadine ;

Welsch, Sonja ;

Krijnse-Locker, Jacomine ;

Banting, George ;

Kraeusslich, Hans-Georg ;

Fackler, Oliver T. ;

Keppler, Oliver T. .

CELL HOST & MICROBE, 2009, 5 (03) :285-297

[9] VPU PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENHANCES THE RELEASE OF CAPSIDS PRODUCED BY GAG GENE CONSTRUCTS OF WIDELY DIVERGENT RETROVIRUSES [J].

GOTTLINGER, HG ;

DORFMAN, T ;

COHEN, EA ;

HASELTINE, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :7381-7385

[10] Zinc-binding domain of rotavirus NSP1 is required for proteasome-dependent degradation of IRF3 and autoregulatory NSP1 stability [J].

Graff, Joel W. ;

Ewen, Julie ;

Ettayebi, Khalil ;

Hardy, Michele E. .

JOURNAL OF GENERAL VIROLOGY, 2007, 88 :613-620

← 1 2 3 →