Simulating T-cell motility in the lymph node paracortex with a packed lattice geometry

被引:34
作者
Bogle, Gib [1 ,2 ]
Dunbar, P. Rod [2 ,3 ]
机构
[1] Univ Auckland, Bioengn Inst, Auckland 1142, New Zealand
[2] Univ Auckland, Maurice Wilkins Ctr, Auckland 1142, New Zealand
[3] Univ Auckland, Sch Biol Sci, Auckland 1142, New Zealand
基金
英国惠康基金;
关键词
lattice; motility; random walk; simulation; T cell;
D O I
10.1038/icb.2008.60
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Agent-based simulation modelling of T-cell trafficking, activation and proliferation in the lymph node paracortex requires a model for cell motility. Such a model must be able to reproduce the observed random-walk behaviour of T cells, while accommodating large numbers of tightly packed cells, and must be computationally efficient. We report the development of a motility model, based on a three-dimensional lattice geometry, that meets these objectives. Cells make discrete jumps between neighbouring lattice sites in directions that are randomly determined from specified discrete probability distributions, which are defined by a small number of parameters. It is shown that the main characteristics of the random motion of T cells as typically observed in vivo can be reproduced by suitable specification of model parameters. The model is computationally highly efficient and provides a suitable engine for a model capable of simulating the full T-cell population of the paracortex.
引用
收藏
页码:676 / 687
页数:12
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