Genetic sampling error of distance (δμ)2 and variation in mutation rate among microsatellite loci

被引：9

作者：

Zhivotovsky, LA

Goldstein, DB

Feldman, MW ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

[2] Vavilov Inst Gen Genet, Moscow, Russia

[3] UCL, Dept Biol, London, England

[4] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2001年 / 18卷 / 12期

关键词：

microsatellite loci; mutation rate; genetic distance;

D O I：

10.1093/oxfordjournals.molbev.a003759

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An expression is obtained for the time-dependent variance of the microsatellite genetic distance (delta mu)(2) when the mutation rate is allowed to vary randomly among loci. An estimator is presented for the coefficient of variation, C-w, in the mutation rate. Estimated values of C-w from genetic distances between African and non-African populations were less than 100%. Caveats to this conclusion are discussed.

引用

收藏

页码：2141 / 2145

页数：5

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