[1] Addenbrookes Hosp, Cambridge Inst Med Res, Dept Clin Biochem, Cambridge CB2 2XY, England
[2] Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med, Cambridge CB2 2XY, England
[3] Univ Cambridge, Dept Physiol, Cambridge CB2 3EG, England
[4] Paradigm Therapeut, Cambridge CB4 0WA, England
[5] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
[6] Univ Manchester, Fac Med, Manchester M13 9PT, Lancs, England
[7] Univ Cambridge, Hutchinson Med Res Council Res Ctr, Dept Oncol, Cambridge CB2 2XZ, England
[8] Univ Oxford, Dept Biochem, Genet Unit, Oxford OX1 3QU, England