Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis

被引:94
作者
Duits, AJ
Pieters, RC
Saleh, AW
VanRosmalen, E
Katerberg, H
Berend, K
Rojer, RA
机构
[1] ST ELIZABETH HOSP,DEPT INTERNAL MED,WASHINGTON,DC
[2] ST ELIZABETH HOSP,CLIN LAB DEPT,WASHINGTON,DC
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1996年 / 81卷 / 01期
关键词
D O I
10.1006/clin.1996.0163
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Adhesion of sickle erythrocytes to vascular endothelium plays a central role in sickle cell disease complications. Cytokines and adhesion molecules are critically involved in the regulation of these adhesive processes. To analyze their role, IL-6, GM-CSF, sVCAM-1, sICAM-1, sE-Selectin, and sP-Selectin serum levels were determined in sickle cell patients under basic conditions and during vasoocclusive crisis, In nonsymptomatic patients a high serum level of sVCAM-1 was observed compared to controls. In patients having vasoocclusive crisis sVCAM-1 levels increased even more and seemed to correlate with crisis evolution. (C) 1996 Academic Press, Inc.
引用
收藏
页码:96 / 98
页数:3
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