Combined kidney and liver transplantation for familial haemolytic uraemic syndrome

被引：124

作者：

Remuzzi, G ^{[1
]}

Ruggenenti, P

Codazzi, D

Noris, M

Caprioli, J

Locatelli, G

Gridelli, B

机构：

[1] Osped Riuniti Bergamo, I-24100 Bergamo, Italy

[2] Mario Negri Inst Pharmacol Res, I-24100 Bergamo, Italy

来源：

LANCET | 2002年 / 359卷 / 9318期

关键词：

D O I：

10.1016/S0140-6736(02)08560-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recurrent haemolytic uraemic syndrome (HUS) is a genetic form of thrombotic microangiopathy that is mostly associated with low activity of complement factor H. The disorder usually develops in families, leads to end stage renal disease, and invariably recurs after kidney transplantation. We did a simultaneous kidney and liver transplantation in a 2-year-old child with HUS and a mutation in complement factor H to restore the defective factor H, with no recurrence of the disease. The operation was successful, and at discharge, the child had healthy kidney and liver function, with no sign of haemolysis.

引用

页码：1671 / 1672

页数：2