Enantioseparations by electrochromatography with packed capillaries

被引:104
作者
Wolf, C
Spence, PL
Pirkle, WH
Derrico, EM
Cavender, DM
Rozing, GP
机构
[1] UNIV ILLINOIS,SCH CHEM SCI,URBANA,IL 61801
[2] HEWLETT PACKARD CORP,WILMINGTON,DE 19808
[3] HEWLETT PACKARD GMBH,WALDBRONN ANALYT DIV,D-76337 WALDBRONN,GERMANY
关键词
electrochromatography; enantiomer separation; chiral stationary phases;
D O I
10.1016/S0021-9673(97)00863-7
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
(S)-Naproxen-derived and (SR,4S)-Whelk-O chiral stationary phases (CSPs) were immobilized on 3 mu m silica supports and packed into 100 mu m I.D. fused-silica capillaries. Enantiomers of some neutral analytes representing a variety of different classes of compounds were separated by electrochromatography using 2-(N-morpholino)ethanesulfonic acid modified with acetonitrile as the buffer system. High column efficiency (up to 200 000 plates per meter) and substantial levels of enantioselectivity were obtained in all cases with separations usually being performed in less than 10 min. (C) 1997 Elsevier Science B.V.
引用
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页码:175 / 179
页数:5
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