Risk Factors of Breast Cancer: A Systematic Review and Meta-Analysis

被引：117

作者：

Anothaisintawee, Thunyarat ^{[1
]}

Wiratkapun, Cholatip ^{[1
]}

Lerdsitthichai, Panuwat ^{[1
]}

Kasamesup, Vijj ^{[1
]}

Wongwaisayawan, Sansanee ^{[1
]}

Srinakarin, Jiraporn ^{[2
]}

Hirunpat, Siriporn ^{[3
]}

Woodtichartpreecha, Piyanoot ^{[3
]}

Boonlikit, Sarawan ^{[4
]}

Teerawattananon, Yot ^{[5
]}

Thakkinstian, Ammarin ^{[1
]}

机构：

[1] Mahidol Univ, Ramathibodi Hosp, Bangkok 10400, Thailand

[2] Khon Kaen Univ, Srinagarind Hosp, Khon Kaen, Thailand

[3] Prince Songkla Univ, Hat Yai, Thailand

[4] Natl Canc Inst, Bangkok, Thailand

[5] Minist Publ Hlth, Nonthaburi, Thailand

来源：

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH | 2013年 / 25卷 / 05期

关键词：

breast cancer; meta-analysis; risk factor; systematic review; HORMONE-REPLACEMENT THERAPY; ORAL-CONTRACEPTIVE USE; ESTROGEN PLUS PROGESTIN; CARCINOMA IN-SITU; POPULATION-BASED COHORT; HISPANIC WHITE WOMEN; BODY-MASS INDEX; POSTMENOPAUSAL WOMEN; REPRODUCTIVE FACTORS; DIABETES-MELLITUS;

D O I：

10.1177/1010539513488795

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

The etiology of breast cancer might be explained by 2 mechanisms, namely, differentiation and proliferation of breast epithelial cells mediated by hormonal factors. We performed a systematic review and meta-analysis to update effects of risk factors for both mechanisms. MEDLINE and EMBASE were searched up to January 2011. Studies that assessed association between oral contraceptives (OC), hormonal replacement therapy (HRT), diabetes mellitus (DM), or breastfeeding and breast cancer were eligible. Relative risks with their confidence intervals (CIs) were extracted. A random-effects method was applied for pooling the effect size. The pooled odds ratios of OC, HRT, and DM were 1.10 (95% CI = 1.03-1.18), 1.23 (95% CI = 1.21-1.25), and 1.14 (95% CI = 1.09-1.19), respectively, whereas the pooled odds ratio of ever-breastfeeding was 0.72 (95% CI = 0.58-0.89). Our study suggests that OC, HRT, and DM might increase risks, whereas breastfeeding might lower risks of breast cancer.

引用

页码：368 / 387

页数：20

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