Differential effects of fibroblast growth factor (FGF) 9 and FGF2 on proliferation, differentiation and terminal differentiation of chondrocytic cells in vitro

被引：64

作者：

Weksler, NB

Lunstrum, GP

Reid, ES

Horton, WA ^{[1
]}

机构：

[1] Portland Shriners Hosp, Dept Res, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA

来源：

BIOCHEMICAL JOURNAL | 1999年 / 342卷

关键词：

apoptosis; chondrogenesis; receptors; signal transduction;

D O I：

10.1042/0264-6021:3420677

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibroblast growth factor (FGF) 9 was compared with FGF2 in its ability to influence proliferation, differentiation, terminal differentiation and apoptosis in a rat calvaria-derived cell line (RCJ 3.1C5.18) that spontaneously undergoes chondrocyte differentiation in vitro. Like FGF2, FGF9 promoted proliferation, but to a lesser extent. In contrast to FGF2, which blocked chondrocytic differentiation, FGF9 had no effect on differentiation but inhibited terminal differentiation. FGF9 also stimulated expression of the mitotic inhibitor p21 to a greater extent than FGF2. Neither ligand influenced apoptosis. The results indicate that FGF9 could account for many of the physiological responses attributed to FGF-receptor activation in the growth plate.

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收藏

页码：677 / 682

页数：6

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