To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps

被引：392

作者：

Boeltz, Sebastian ^{[1
,2
]}

Amini, Poorya ^{[3
]}

Anders, Hans-Joachim ^{[4
]}

Andrade, Felipe ^{[5
]}

Bilyy, Rostyslav ^{[6
]}

Chatfield, Simon ^{[7
]}

Cichon, Iwona ^{[8
]}

Clancy, Danielle M. ^{[9
]}

Desai, Jyaysi ^{[4
]}

Dumych, Tetiana ^{[6
]}

Dwivedi, Nishant ^{[10
,11
]}

Gordon, Rachael Ann ^{[12
]}

Hahn, Jonas ^{[1
,2
]}

Hidalgo, Andres ^{[13
,14
]}

Hoffmann, Markus H. ^{[1
,2
]}

Kaplan, Mariana J. ^{[15
]}

Knight, Jason S. ^{[16
]}

Kolaczkowska, Elzbieta ^{[8
]}

Kubes, Paul ^{[17
]}

Leppkes, Moritz ^{[18
]}

Manfredi, Angelo A. ^{[19
,20
]}

Martin, Seamus J. ^{[21
]}

Maueroder, Christian ^{[1
,2
,9
]}

Maugeri, Norma ^{[19
,20
]}

Mitroulis, Ioannis ^{[22
,23
]}

Munoz, Luis E. ^{[1
,2
]}

Nakazawa, Daigo ^{[4
]}

Neeli, Indira ^{[24
]}

Nizet, Victor ^{[25
,26
]}

Pieterse, Elmar ^{[27
]}

Radic, Marko Z. ^{[24
]}

Reinwald, Christiane ^{[1
,2
]}

Ritis, Konstantinos ^{[22
,23
]}

Rovere-Querini, Patrizia ^{[19
,20
]}

Santocki, Michal ^{[8
]}

Schauer, Christine ^{[1
,2
]}

Schett, Georg ^{[1
,2
]}

Shlomchik, Mark Jay ^{[12
]}

Simon, Hans-Uwe ^{[3
,28
]}

Skendros, Panagiotis ^{[22
,23
]}

Stojkov, Darko ^{[3
]}

Vandenabeele, Peter ^{[9
,29
,30
]}

Vanden Berghe, Tom ^{[9
,29
,31
]}

van der Vlag, Johan ^{[27
]}

Vitkov, Ljubomir ^{[32
,33
]}

von Koeckritz-Blickwede, Maren ^{[34
,35
]}

Yousefi, Shida ^{[3
]}

Zarbock, Alexander ^{[36
]}

Herrmann, Martin ^{[1
,2
]}

机构：

[1] Friedrich Alexander Univ FAU Erlangen Nurnberg, Dept Internal Med Rheumatol & Immunol 3, D-91054 Erlangen, Germany

[2] Univ Klinikum Erlangen, D-91054 Erlangen, Germany

[3] Univ Bern, Inst Pharmacol, Bern, Switzerland

[4] Klinikum Univ Munchen, Med Klin & Poliklin 4, Munich, Germany

[5] Johns Hopkins Univ, Sch Med, Div Rheumatol, Baltimore, MD USA

[6] Danylo Halytsky Lviv Natl Med Univ, Lvov, Ukraine

[7] Walter & Eliza Hall Inst Med Res, Inflammat Div, Melbourne, Vic, Australia

[8] Jagiellonian Univ, Inst Zool & Biomed Res, Dept Expt Hematol, Krakow, Poland

[9] Univ Ghent, VIB UGent Ctr Inflammat Res, Ghent, Belgium

[10] Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, Dept Med, 75 Francis St, Boston, MA 02115 USA

[11] Harvard Med Sch, Boston, MA USA

[12] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA USA

[13] Fdn Ctr Nacl Invest Cardiovasc CNIC Carlos III, Dept Cell & Dev Biol, Madrid, Spain

[14] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, Munich, Germany

[15] NIAMSD, Syst Autoimmun Branch, NIH, Bethesda, MD 20892 USA

[16] Univ Michigan, Div Rheumatol, Ann Arbor, MI 48109 USA

[17] Univ Calgary, Snyder Inst Chron Dis, Calgary, AB, Canada

[18] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Dept Med Gastroenterol Pulmonol & Endocrinol 1, Erlangen, Germany

[19] Univ Vita Salute San Raffaele, Milan, Italy

[20] IRCCS Osped San Raffaele, Milan, Italy

[21] Trinity Coll Dublin, Mol Cell Biol Lab, Dept Genet, Smurfit Inst, Dublin 2, Ireland

[22] Democritus Univ Thrace, Lab Mol Hematol, Dept Med, Alexandroupolis, Greece

[23] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Internal Med 1, Alexandroupolis, Greece

[24] Univ Tennessee, Hlth Sci Ctr, Dept Microbiol Immunol & Biochem, Memphis, TN 38163 USA

[25] Univ Calif San Diego, Sch Med, La Jolla, CA USA

[26] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA USA

[27] Radboud Univ Nijmegen, Med Ctr, Dept Nephrol, Radboud Inst Mol Life Sci, Nijmegen, Netherlands

[28] Sechenov Univ, Dept Clin Immunol & Allergol, Moscow, Russia

[29] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium

[30] Univ Ghent, Methusalem Platform, Ghent, Belgium

[31] Univ Antwerp, Lab Pathophysiol, Fac Biomed Sci, Antwerp, Belgium

[32] Univ Salzburg, Dept Biosci, Vasc & Exercise Biol Unit, Salzburg, Austria

[33] Saarland Univ, Periodontol & Prevent Dent, Homburg, Germany

[34] Univ Vet Med Hannover, Dept Physiol Chem, Hannover, Germany

[35] Univ Vet Med Hannover, Res Ctr Emerging Infect & Zoonosis RIZ, Hannover, Germany

[36] Univ Munster, Dept Anesthesiol Intens Care & Pain Med, Munster, Germany

来源：

CELL DEATH AND DIFFERENTIATION | 2019年 / 26卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; PROTEIN ARGININE DEIMINASE; CELL-DEATH; MITOCHONDRIAL-DNA; MOUSE MODEL; NETOSIS; RELEASE; QUANTIFICATION; INNATE; AUTOIMMUNE;

D O I：

10.1038/s41418-018-0261-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.

引用

页码：395 / 408

页数：14

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