Germ line polymorphism in metastatic progression

被引：33

作者：

Hunter, KW ^{[1
]}

Crawford, NP ^{[1
]}

机构：

[1] NCI, Lab Populat Genet, Canc Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 03期

关键词：

D O I：

10.1158/0008-5472.CAN-05-3705

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Somatic genetic analysis of tumors and metastases has yielded a plethora of information regarding genes associated with cancer progression. However, somatic alterations in tumor cells are only one source of variability. Genetic polymorphism may also play a significant role in personto-person variability in metastasis frequency, raising the intriguing possibility that some individuals could be predisposed to secondary tumor development. The identification and characterization of these polymorphisms may have significant implications for the development of tailored treatment or prevention of recurrent disease.

引用

页码：1251 / 1254

页数：4

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