Isoprostanes - Prostaglandin-like compounds formed in vivo independently of cyclooxygenase - Use as clinical indicators of oxidant damage

被引：62

作者：

Awad, JA ^{[1
]}

Roberts, JL ^{[1
]}

Burk, RF ^{[1
]}

Morrow, JD ^{[1
]}

机构：

[1] VANDERBILT UNIV,DIV CLIN PHARMACOL,NASHVILLE,TN

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 1996年 / 25卷 / 02期

关键词：

D O I：

10.1016/S0889-8553(05)70255-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

F-2-isoprostanes are prostanoids produced independently of cyclooxygenase by free radical-catalyzed peroxidation of arachidonic acid containing lipids. Quantification of F-2-isoprostanes from biological fluids and tissues represents an important advance in the detection and measurement of lipid peroxidation in vivo. In addition, the biophysical effects of isoprostane-containing lipids and the biological effects of free isoprostanes provide potential mechanisms for oxidant stress-related alterations in homeostasis. F-2-isoprostane measurement in experimental models of free radical-induced injury and human disease may allow better design and evaluation of antioxidant therapeutic strategies.

引用

页码：409 / &

页数：21

共 74 条

[1] ACETAMINOPHEN-INDUCED HEPATIC-INJURY IN MICE - THE ROLE OF LIPID-PEROXIDATION AND EFFECTS OF PRETREATMENT WITH COENZYME Q(10) AND ALPHA-TOCOPHEROL [J].