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Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction

被引：90
作者：
Saklatvala, J
Davis, W
Guesdon, F
机构：
[1] Cytokine Laboratory, Department of Development and Signalling, Babraham Institute
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES | 1996年 / 351卷 / 1336期
关键词：
D O I：
10.1098/rstb.1996.0011
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The inflammatory cytokines interleukin 1 (IL1) and tumour necrosis factor (TNF) have a broad range of physiological effects. Whereas their immediate post-receptor events are not well understood, both have the potential to activate a range of protein kinases. These include the three types of mitogen activated protein (MAP) kinase (ERK,JNK/p54 and p38) and a beta-casein kinase. The mechanisms by which these kinases are activated is discussed and the significance of their activation for particular biological responses is assessed.
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页码：151 / 157
页数：7
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