Cryptococcal infections of the central nervous system: An analysis of predisposing factors, laboratory findings and outcome in patients from South India with special reference to HIV infection

被引:46
作者
Khanna, N
Chandramuki, A
Desai, A
Ravi, V
机构
[1] NATL INST MENTAL HLTH & NEUROSCI, DEPT MICROBIOL, BANGALORE 560029, KARNATAKA, INDIA
[2] NATL INST MENTAL HLTH & NEUROSCI, DEPT NEUROVIROL, BANGALORE 560029, KARNATAKA, INDIA
关键词
D O I
10.1099/00222615-45-5-376
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The incidence of cryptococcosis in patients with AIDS is significant, Predisposing factors, laboratory findings and outcome were assessed in 60 patients with cryptococcal infections of the central nervous system over a 17.5-year period (Jan, 1978-June 1995). Predisposing factors for cryptococcal infection were identified in 36 patients, with HIV infection being the commonest (18), Cryptococcal cultures were positive in all patients, India ink staining was positive in 48 patients and cryptococcal antigen was detected in 35 of 36 patients tested, Comparison of clinical and laboratory parameters between HIV-positive and HIV-negative patients showed that CSF cell response was poorer, culture of cryptococci from non-neural sites mas more frequent and mortality was higher in the HIV-positive group, Although not statistically significant, concurrent systemic infections, especially tuberculosis, were more frequent in the HIV-positive group.
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页码:376 / 379
页数:4
相关论文
共 14 条
[1]   INFECTIONS WITH CRYPTOCOCCUS-NEOFORMANS IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].
CHUCK, SL ;
SANDE, MA .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (12) :794-799
[2]  
CLARK RA, 1990, REV INFECT DIS, V12, P768
[3]   FALSE-NEGATIVE CEREBROSPINAL-FLUID CRYPTOCOCCAL LATEX AGGLUTINATION TESTS FOR PATIENTS WITH CULTURE-POSITIVE CRYPTOCOCCAL MENINGITIS [J].
CURRIE, BP ;
FREUNDLICH, LF ;
SOTO, MA ;
CASADEVALL, A .
JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (09) :2519-2522
[4]   CRYPTOCOCCAL MENINGITIS IN PATIENTS WITH AIDS [J].
DISMUKES, WE .
JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (04) :624-628
[5]   DIAGNOSIS OF CRYPTOCOCCAL MENINGITIS - VALUE OF IMMUNOLOGIC DETECTION OF CRYPTOCOCCAL ANTIGEN [J].
GOODMAN, JS ;
KAUFMAN, L ;
KOENIG, MG .
NEW ENGLAND JOURNAL OF MEDICINE, 1971, 285 (08) :434-&
[6]   HYALURONIDASE AS AN ADJUVANT IN THE MANAGEMENT OF TUBERCULOUS SPINAL ARACHNOIDITIS [J].
GOURIEDEVI, M ;
SATISHCHANDRA, P .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1991, 102 (01) :105-111
[7]   VALUE AND INTERPRETATION OF SEROLOGICAL TESTS FOR DIAGNOSIS OF CRYPTOCOCCOSIS [J].
KAUFMAN, L ;
BLUMER, S .
APPLIED MICROBIOLOGY, 1968, 16 (12) :1907-&
[8]  
KAUR A, 1992, J ACQ IMMUN DEF SYND, V5, P883
[9]   VIRULENCE FACTORS OF CRYPTOCOCCUS-NEOFORMANS [J].
KOZEL, TR .
TRENDS IN MICROBIOLOGY, 1995, 3 (08) :295-299
[10]   EPIDEMIOLOGIC DIFFERENCES BETWEEN THE 2 VARIETIES OF CRYPTOCOCCUS-NEOFORMANS [J].
KWONCHUNG, KJ ;
BENNETT, JE .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1984, 120 (01) :123-130