Adiponectin and cancer: a systematic review

被引：379

作者：

Kelesidis, I ^{[1
]}

Kelesidis, T ^{[1
]}

Mantzoros, C ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

来源：

BRITISH JOURNAL OF CANCER | 2006年 / 94卷 / 09期

关键词：

obesity; insulin resistance; adipocytokines; adiponectin;

D O I：

10.1038/sj.bjc.6603051

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have demonstrated that obesity is a significant risk factor for the development of several malignancies, but the mechanisms underlying this relationship remain to be fully elucidated. Adiponectin, an adipocyte secreted endogenous insulin sensitizer, appears to play an important role not only in glucose and lipid metabolism but also in the development and progression of several obesity-related malignancies. In this review, we present recent findings on the association of adiponectin with several malignancies as well as recent data on underlying molecular mechanisms that provide novel insights into the association between obesity and cancer risk. We also identify important research questions that remain unanswered.

引用

页码：1221 / 1225

页数：5

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