The protease-activated receptor2 (PAR2)-prostaglandin E2-prostanoid EP receptor axis:: A potential bronchoprotective unit in the respiratory tract?

被引：26

作者：

Henry, PJ ^{[1
]}

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2006年 / 533卷 / 1-3期

基金：

英国医学研究理事会;

关键词：

protease-activated receptor; prostaglandin E-2; prostanoid receptor; respiratory tract;

D O I：

10.1016/j.ejphar.2005.12.051

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Protease-activated receptor, (PAR(2)) is a subtype of G protein-coupled receptor that is widely expressed within the respiratory tract. Stimulation of PAR(2) by proteases such as trypsin and tryptase, or by small peptidic activators induces a complex array of effects within the airways. One such PAR-mediated effect by basal airway epithelial cells is the generation of prostaglandin E-2. Prostaglandin E-2 produces a raft of anti-inflammatory effects within the airways, principally through the activation of the prostanoid EP2 and EP3 receptor subtypes. This article reviews the PAR,prostaglandin E-2-prostanoid EP receptor axis and discusses approaches through which its activation may provide beneficial effects in respiratory disease. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：156 / 170

页数：15

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