Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks

被引：67

作者：

Bender, Roland A. ^{[1
,2
,3
,4
]}

Baram, Tallie Z. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Irvine, Dept Anat Neurobiol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA

[4] Univ Hamburg, Inst Anat 1, D-20246 Hamburg, Germany

来源：

PROGRESS IN NEUROBIOLOGY | 2008年 / 86卷 / 03期

关键词：

Ion channels; Hippocampus; Epilepsy; I-h; HCN channels; Hyperpolarization; Hyperpolarization-activated; Development; Resonance; Seizures; Heteromerization; Synaptic plasticity;

D O I：

10.1016/j.pneurobio.2008.09.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Developing neuronal networks evolve continuously, requiring that neurons modulate both their intrinsic properties and their responses to incoming synaptic signals. Emerging evidence supports roles for the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in this neuronal plasticity. HCN channels seem particularly suited for fine-tuning neuronal properties and responses because of their remarkably large and variable repertoire of functions, enabling integration of a wide range of cellular signals. Here, we discuss the involvement of HCN channels in cortical and hippocampal network maturation, and consider potential roles of developmental HCN channel dysregulation in brain disorders such as epilepsy. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：129 / 140

页数：12

共 177 条

[1]

Agmon A, 2003, J NEUROSCI, V23, P3658

[2] Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node [J].