Virulence of Streptococcus pneumoniae may be determined independently of capsular polysaccharide

被引：33

作者：

Nebenzahl, YM ^{[1
]}

Porat, N

Lifshitz, S

Novick, S

Levi, A

Ling, E

Liron, O

Mordechai, S

Sahu, RK

Dagan, R

机构：

[1] Ben Gurion Univ Negev, Dept Microbiol & Immunol, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Ctr Canc Res, IL-84105 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Soroka Med Ctr, Pediat Infect Dis Unit, IL-84105 Beer Sheva, Israel

[4] Ben Gurion Univ Negev, Dept Epidemiol, IL-84105 Beer Sheva, Israel

[5] Ben Gurion Univ Negev, Dept Phys, IL-84105 Beer Sheva, Israel

来源：

FEMS MICROBIOLOGY LETTERS | 2004年 / 233卷 / 01期

关键词：

Streptococcus pneumoniae; capsular polysaccharide; virulence factors; microbial pathogenesis;

D O I：

10.1016/j.femsle.2004.02.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mice were inoculated intranasally with Streptococcus pneumoniae isolates of serotype 14 with different genetic backgrounds (14R, 14DW) and a capsular switch of 14R, strain 9VR (serotype 9V). Inoculation of the mice with 14R and 9VR resulted in 60% mortality. All the mice survived 14DW inoculation. No differences in lungs' bacterial loads were found 3 It following inoculation. Bacterial clearance of 5 logs was observed 48 h after inoculation with 14DW versus within I log 48 h after inoculation with 14R and 9VR. No significant differences in bacterial size or the capsular amount could be found between 14R and 14DW. We conclude that factor(s) in addition to the capsule, contribute to disease outcome. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：147 / 152

页数：6

共 28 条

[1]

AUSTRIAN R, 1976, MT SINAI J MED, V43, P699

[2] Chemo-immunological studies on conjugated carbohydrate-proteins II. Immunological specificity of synthetic sugar-protein antigens [J].

Avery, OT ;

Goebel, WF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1929, 50 (04) :533-550

[3]

BROWN EJ, 1985, CURR TOP MICROBIOL, V121, P159

[4] Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential [J].

Brueggemann, AB ;

Griffiths, DT ;

Meats, E ;

Peto, T ;

Crook, DW ;

Spratt, BG .

JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (09) :1424-1432

[5] Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide-specific immunoglobulin isotype responses in vivo through distinct mechanisms [J].

Colino, J ;

Shen, Y ;

Snapper, CM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (01) :1-13

[6] Reduction of pneumococcal nasopharyngeal carriage in early infancy after immunization with tetravalent pneumococcal vaccines conjugated to either tetanus toxoid or diphtheria toxoid [J].

Dagan, R ;

Muallem, M ;

Melamed, R ;

Leroy, O ;

Yagupsky, P .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1997, 16 (11) :1060-1064

[7] The contribution of specific pneumococcal serogroups to different disease manifestations: Implications for conjugate vaccine formulation and use, part II [J].

Hausdorff, WP ;

Bryant, J ;

Kloek, C ;

Paradiso, PR ;

Siber, GR .

CLINICAL INFECTIOUS DISEASES, 2000, 30 (01) :122-140

[8] Pneumococcal virulence factors: Structure and function [J].

Jedrzejas, MJ .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2001, 65 (02) :187-+

[9] Streptococcal adhesion and colonization [J].

Jenkinson, HF ;

Lamont, RJ .

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1997, 8 (02) :175-200

[10] Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type [J].

Kadioglu, A ;

Taylor, S ;

Iannelli, F ;

Pozzi, G ;

Mitchell, TJ ;

Andrew, PW .

INFECTION AND IMMUNITY, 2002, 70 (06) :2886-2890

← 1 2 3 →