Concise Review: Organ Engineering: Design, Technology, and Integration

被引：51

作者：

Kaushik, Gaurav ^{[1
,2
]}

Leijten, Jeroen ^{[1
,2
,3
]}

Khademhosseini, Ali ^{[1
,2
,4
,5
,6
]}

机构：

[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Biomat Innovat Res Ctr, Dept Med, Cambridge, MA USA

[3] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Dev BioEngn, Enschede, Netherlands

[4] King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia

[5] Konkuk Univ, Coll Anim Biosci & Technol, Dept Bioind Technol, Seoul, South Korea

[6] King Abdulaziz Univ, Dept Phys, Jeddah, Saudi Arabia

来源：

STEM CELLS | 2017年 / 35卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Organ engineering; Tissue engineering; Three-dimensional printing; Microfluidics; Developmental biology; ARNT-LIKE; 1; ON-A-CHIP; STEM-CELLS; CARDIOMYOCYTE DIFFERENTIATION; DROSOPHILA-MELANOGASTER; EXTRACELLULAR-MATRIX; MECHANICAL-STRESS; TISSUE; HYDROGELS; BIOMATERIALS;

D O I：

10.1002/stem.2502

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling technologies including biocompatible biomaterials and biofabrication platforms such as three-dimensional bioprinting. When engineering complex tissues and organs, core design principles must be taken into account, such as the structure-function relationship, biochemical signaling, mechanics, gradients, and spatial constraints. Technological advances in biomaterials, biofabrication, and biomedical imaging allow for in vitro control of these factors to recreate in vivo phenomena. Finally, organ engineering emerges as an integration of biological design and technical rigor. An overall workflow for organ engineering and guiding technology to advance biology as well as a perspective on necessary future iterations in the field is discussed.

引用

页码：51 / 60

页数：10

共 117 条

[1]

Three-Dimensional Printing of the Skin [J].