Under pressure: Stromal fibroblasts change their ways

被引：18

作者：

Bierie, B

Moses, HL

机构：

[1] Vanderbilt Univ, Ctr Med, Dept Canc Biol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Ctr Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

来源：

CELL | 2005年 / 123卷 / 06期

关键词：

D O I：

10.1016/j.cell.2005.11.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression.

引用

收藏

页码：985 / 987

页数：3

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