Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology

被引：232

作者：

Racioppi, Luigi ^{[1
,2
,3
]}

Means, Anthony R. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[3] Univ Naples Federico II, Dept Cellular & Mol Biol & Pathol, I-80131 Naples, Italy

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 38期

基金：

美国国家卫生研究院;

关键词：

RUNX TRANSCRIPTION FACTORS; GRANULE CELL-DEVELOPMENT; MOLECULAR-CLONING; INFLAMMATORY RESPONSES; NEURONAL DEVELOPMENT; BODY-WEIGHT; FOOD-INTAKE; CAMKK-BETA; BONE MASS; CALMODULIN;

D O I：

10.1074/jbc.R112.356485

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many cellular Ca-2+ -dependent signaling cascades utilize calmodulin (CaM) as the intracellular Ca2+ receptor. Ca2+/CaM binds and activates a plethora of enzymes, including CaM kinases (CaMKs). CaMKK2 is one of the most versatile of the CaMKs and will phosphorylate and activate CaMKI, CaMKIV, and AMP-activated protein kinase. Cell expression of CaMKK2 is limited, yet CaMKK2 is involved in regulating many important physiological and pathophysiological processes, including energy balance, adiposity, glucose homeostasis, hematopoiesis, inflammation, and cancer. Here, we explore known functions of CaMKK2 and discuss its potential as a target for therapeutic intervention.

引用

页码：31658 / 31665

页数：8

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