Booster vaccination with recombinant hepatitis B vaccine four years after priming with one single dose

被引：46

作者：

Wiström, J ^{[1
]}

Ahlm, C

Lundberg, S

Settergren, B

Tärnvik, A

机构：

[1] Univ Umea Hosp, Dept Infect Dis, S-90185 Umea, Sweden

[2] Danderyd Hosp, Dept Infect Dis, S-18288 Danderyd, Sweden

来源：

VACCINE | 1999年 / 17卷 / 17期

关键词：

hepatitis B; vaccination; immunity;

D O I：

10.1016/S0264-410X(99)00012-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

We here studied the antibody response to a booster dose four years after the administration of one single dose of recombinant HE vaccine. Before receiving the booster dose, levels of protective antibodies (anti-HBs) were generally low and 24/41 (59%) individuals lacked detectable antibodies (<1 IU/L). Within 14 d of booster vaccination, 36/38 (95%) vaccinees showed levels of antibodies > 100 IU/L. Notably, these levels were at least as high as those of a reference group 12 months after initiation of vaccination according to the standard three-dose vaccination at intervals of 0, 1 and 6 months. In conclusion, one single dose of HE vaccine seemed to confer on young healthy individuals a well preserved B cell memory, disclosed as a rapid and strong antibody response to a second dose four years later. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2162 / 2165

页数：4

共 15 条

[1]

Prediction of response to hepatitis B vaccine in health care workers: Whose titers of antibody to hepatitis B surface antigen should be determined after a three-dose series, and what are the implications in terms of cost-effectiveness? [J].