Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygenation

被引：24

作者：

Chalwin, Richard P. ^{[1
]}

Tiruvoipati, Ravindranath ^{[1
]}

Peek, Giles J. ^{[1
]}

机构：

[1] Glenfield Gen Hosp, Dept ECMO, Leicester LE3 9QP, Leics, England

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 2008年 / 34卷 / 03期

关键词：

Extracorporeal membrane oxygenation; Thrombosis; Bleeding;

D O I：

10.1016/j.ejcts.2008.05.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bleeding remains a potential complication for patients requiring extracorporeal life support systems. Recombinant activated factor VII (rFVIIa) is one of the drugs used in controlling bleeding. Its use is generally found to be safe. We report a paediatric patient who developed fatal thrombosis with the use of rFVIIa whilst on extracorporeal membrane oxygenation and discuss the possible factors that lead to fatal thrombosis. Crown Copyright (c) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

引用

页码：685 / 686

页数：2

共 8 条

[1] Effect of the administration of recombinant activated factor VII (rFVIIa; NovoSeven®) in the management of severe uncontrolled bleeding in patients undergoing heart valve replacement surgery [J].

Al Douri, M ;

Shafi, T ;

Al Khudairi, D ;

Al Bokhari, E ;

Black, L ;

Akinwale, N ;

Musa, MO ;

Al Homaidhi, A ;

Al Fagih, M ;

Andreasen, RB .

BLOOD COAGULATION & FIBRINOLYSIS, 2000, 11 :S121-S127

[2]

Dominguez T E, 2005, Pediatr Crit Care Med, V6, P348, DOI 10.1097/01.PCC.0000161623.51275.0F

[3] Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding:: A systematic review [J].

Levi, M ;

Peters, M ;

Büller, HR .

CRITICAL CARE MEDICINE, 2005, 33 (04) :883-890

[4] Safety profile of recombinant factor VIIa [J].

Roberts, HR ;

Monroe, DM ;

Hoffman, M .

SEMINARS IN HEMATOLOGY, 2004, 41 (01) :101-108

[5] Administration of recombinant activated factor VII (NovoSeven) in three cases of uncontrolled bleeding caused by disseminated intravascular coagulopathy [J].

Schmid, Stefan ;

Friesenecker, Barbara ;

Lorenz, Ingo ;

Innerhofer, Petra ;

Koscielny, Juergen ;

Velik-Salchner, Corinna ;

Mutz, Norbert ;

Fries, Dietmar .

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2007, 13 (03) :313-317

[6] Activated recombinant factor VII in cardiac surgery [J].

Steiner, Marie E. ;

Key, Nigel S. ;

Levy, Jerrold H. .

CURRENT OPINION IN ANESTHESIOLOGY, 2005, 18 (01) :89-92

[7]

Tanos Marios, 2006, Interact Cardiovasc Thorac Surg, V5, P493, DOI 10.1510/icvts.2006.134791

[8]

Wittenstein Birgit, 2005, Pediatr Crit Care Med, V6, P473, DOI 10.1097/01.PCC.0000162449.55887.B9

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