RNA recognition by HIV-1 Tat and Rev

被引：12

作者：

Tan, RY ^{[1
]}

Brodsky, A

Williamson, JR

Frankel, AD

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

SEMINARS IN VIROLOGY | 1997年 / 8卷 / 03期

关键词：

arginine-rich motif; RNA-protein interactions; RRE; TAR;

D O I：

10.1006/smvy.1997.0121

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 Tat and Rev, two essential regulatory proteins, contain arginine-rich domains that are largely responsible for specific binding to their respective RNA sites, TAR and RRE. Structural studies demonstrate how these RNAs provide precise three-dimensional frameworks for protein binding. In vivo, Tat and Rev interact with additional cellular proteins to carry out their important roles in viral transcription and mRNA processing and transport. (C) 1997 Academic Press.

引用

页码：186 / 193

页数：8

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