The structure of porcine parvovirus:: Comparison with related viruses

被引:121
作者
Simpson, AA
Hébert, B
Sullivan, GM
Parrish, CR
Zádori, Z
Tijssen, P
Rossmann, MG
机构
[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
[2] Cornell Univ, Coll Vet Med, James A Baker Inst Anim Hlth, Ithaca, NY 14853 USA
[3] Univ Quebec, Inst Armand Frappier, INRS, Laval, PQ H7V 1B7, Canada
基金
美国国家卫生研究院; 加拿大自然科学与工程研究理事会;
关键词
porcine parvovirus; X-ray crystallography; structure; host range; tissue tropism;
D O I
10.1006/jmbi.2001.5319
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The structure of baculovirus-expressed porcine parvovirus (PPV) capsids was solved using X-ray crystallography and was found to be similar to the related canine parvovirus (CPV) and minute virus of mice (MVM). The PPV capsid protein has 57% and 49% amino acid sequence identity with CPV and MVM, respectively, but the degree of conservation of surface-exposed residues is lower than average. Consequently, most of the structural differences are on the surface and are the probable cause of the known variability in antigenicity and host range. The NADL-2 and Kresse strains of PPV have distinct tissue tropisms and pathogenicity, which are mediated by one or more of the amino acid residues 381, 386, and 436. These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions. (C) 2002 Elsevier Science Ltd.
引用
收藏
页码:1189 / 1198
页数:10
相关论文
共 37 条
  • [1] STRUCTURE DETERMINATION OF FELINE PANLEUKOPENIA VIRUS EMPTY PARTICLES
    AGBANDJE, M
    MCKENNA, R
    ROSSMANN, MG
    STRASSHEIM, ML
    PARRISH, CR
    [J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1993, 16 (02): : 155 - 171
  • [2] Functional implications of the structure of the murine parvovirus, minute virus of mice
    Agbandje-McKenna, M
    Llamas-Saiz, AL
    Wang, F
    Tattersall, P
    Rossmann, MG
    [J]. STRUCTURE WITH FOLDING & DESIGN, 1998, 6 (11): : 1369 - 1381
  • [3] Genome organization of the Kresse strain of porcine parvovirus: Identification of the allotropic determinant and comparison with those of NADL-2 and field isolates
    Bergeron, J
    Hebert, B
    Tijssen, P
    [J]. JOURNAL OF VIROLOGY, 1996, 70 (04) : 2508 - 2515
  • [4] BLOOM ME, 2001, FIELDS VIROLOGY, V2, P2361
  • [5] ERYTHROCYTE-P ANTIGEN - CELLULAR RECEPTOR FOR B19 PARVOVIRUS
    BROWN, KE
    ANDERSON, SM
    YOUNG, NS
    [J]. SCIENCE, 1993, 262 (5130) : 114 - 117
  • [6] Crystallography & NMR system:: A new software suite for macromolecular structure determination
    Brunger, AT
    Adams, PD
    Clore, GM
    DeLano, WL
    Gros, P
    Grosse-Kunstleve, RW
    Jiang, JS
    Kuszewski, J
    Nilges, M
    Pannu, NS
    Read, RJ
    Rice, LM
    Simonson, T
    Warren, GL
    [J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1998, 54 : 905 - 921
  • [7] MULTIPLE AMINO-ACIDS IN THE CAPSID STRUCTURE OF CANINE PARVOVIRUS COORDINATELY DETERMINE THE CANINE HOST RANGE AND SPECIFIC ANTIGENIC AND HEMAGGLUTINATION PROPERTIES
    CHANG, SF
    SGRO, JY
    PARRISH, CR
    [J]. JOURNAL OF VIROLOGY, 1992, 66 (12) : 6858 - 6867
  • [8] STRUCTURE, SEQUENCE, AND FUNCTION CORRELATIONS AMONG PARVOVIRUSES
    CHAPMAN, MS
    ROSSMANN, MG
    [J]. VIROLOGY, 1993, 194 (02) : 491 - 508
  • [9] PATHOGENICITY OF A SKIN ISOLATE OF PORCINE PARVOVIRUS IN SWINE FETUSES
    CHOI, CS
    MOLITOR, TW
    JOO, HS
    GUNTHER, R
    [J]. VETERINARY MICROBIOLOGY, 1987, 15 (1-2) : 19 - 29
  • [10] Controlled conformational transitions in the MVM virion expose the VP1 N-terminus and viral genome without particle disassembly
    Cotmore, SF
    D'Abramo, AM
    Ticknor, CM
    Tattersall, P
    [J]. VIROLOGY, 1999, 254 (01) : 169 - 181