Receptor for Advanced Glycation End Products: A New Theraputic Target for Chronic Obstructive Pulmonary Disease?

被引：7

作者：

Chen, Lei ^{[1
,2
]}

Liu, Lin ^{[3
]}

Wang, Tao ^{[1
,2
]}

Shen, Yong-chun ^{[1
,2
]}

Wen, Fu-qiang ^{[1
,2
]}

机构：

[1] Sichuan Univ, W China Sch Med, W China Hosp, Div Pulm Dis,State Key Lab Biotherapy China, Chengdu 610064, Sichuan, Peoples R China

[2] Sichuan Univ, W China Sch Med, W China Hosp, Dept Resp Med, Chengdu 610064, Sichuan, Peoples R China

[3] 363 Hosp, Dept Resp Med, Chengdu, Sichuan, Peoples R China

来源：

ARCHIVES OF MEDICAL RESEARCH | 2013年 / 44卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Chronic obstructive pulmonary disease; Receptor for advanced glycation end products; SOLUBLE RECEPTOR; CIGARETTE-SMOKE; LUNG INJURY; RAGE; COPD; EXPRESSION;

D O I：

10.1016/j.arcmed.2012.12.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Receptor for advanced glycation end products (RAGE), a multiligand receptor, has been suggested to be implicated in inflammatory response. However, its role in chronic obstructive pulmonary disease (COPD) has not been well elucidated. Recently, several studies reported RAGE and its common ligands were upregulated in airways and lung tissues from COPD smokers. Moreover, inhibition of RAGE activation significantly attenuated cigarette smoke extract or bacteria-induced pulmonary inflammation. Based on these findings, a conclusion could be made that ligand-activated RAGE may play a key role in COPD and thus RAGE could be a new therapeutic target for COPD. (C) 2013 IMSS. Published by Elsevier Inc.

引用

页码：75 / 76

页数：2

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