Increased Recognition of Non-O157 Shiga Toxin-Producing Escherichia coli Infections in the United States During 2000-2010: Epidemiologic Features and Comparison with E. coli O157 Infections

被引：268

作者：

Gould, L. Hannah ^{[1
]}

Mody, Rajal K. ^{[1
]}

Ong, Kanyin L. ^{[1
]}

Clogher, Paula ^{[2
]}

Cronquist, Alicia B. ^{[3
]}

Garman, Katie N. ^{[4
]}

Lathrop, Sarah ^{[5
]}

Medus, Carlota ^{[6
]}

Spina, Nancy L. ^{[7
]}

Webb, Tameka H. ^{[8
]}

White, Patricia L. ^{[9
]}

Wymore, Katie ^{[10
]}

Gierke, Ruth E. ^{[1
]}

Mahon, Barbara E. ^{[1
]}

Griffin, Patricia M. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[2] Connecticut Emerging Infect Program, New Haven, CT USA

[3] Colorado Dept Publ Hlth & Environm, Denver, CO USA

[4] Tennessee Dept Hlth, Nashville, TN USA

[5] New Mexico Emerging Infect Program, Albuquerque, NM USA

[6] Minnesota Dept Hlth, St Paul, MN USA

[7] New York State Emerging Infect Program, Albany, NY USA

[8] Georgia Dept Community Hlth, Div Publ Hlth, Atlanta, GA USA

[9] US Food Safety & Inspect Serv, USDA, Omaha, NE USA

[10] Calif Emerging Infect Program, Oakland, CA USA

来源：

FOODBORNE PATHOGENS AND DISEASE | 2013年 / 10卷 / 05期

基金：

美国农业部;

关键词：

HEMOLYTIC-UREMIC SYNDROME; DIARRHEA; SURVEILLANCE; CHILDREN; MEXICO;

D O I：

10.1089/fpd.2012.1401

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Background: Shiga toxin-producing Escherichia coli (STEC) are an important cause of diarrhea and the major cause of postdiarrheal hemolytic uremic syndrome. Non-O157 STEC infections are being recognized with greater frequency because of changing laboratory practices. Methods: Foodborne Diseases Active Surveillance Network (FoodNet) site staff conducted active, population-based surveillance for laboratory-confirmed STEC infections. We assessed frequency and incidence of STEC infections by serogroup and examined and compared demographic factors, clinical characteristics, and frequency of international travel among patients. Results: During 2000-2010, FoodNet sites reported 2006 cases of non-O157 STEC infection and 5688 cases of O157 STEC infections. The number of reported non-O157 STEC infections increased from an incidence of 0.12 per 100,000 population in 2000 to 0.95 per 100,000 in 2010; while the rate of O157 STEC infections decreased from 2.17 to 0.95 per 100,000. Among non-O157 STEC, six serogroups were most commonly reported: O26 (26%), O103 (22%), O111 (19%), O121 (6%), O45 (5%), and O145 (4%). Non-O157 STEC infections were more common among Hispanics, and infections were less severe than those caused by O157 STEC, but this varied by serogroup. Fewer non-O157 STEC infections were associated with outbreaks (7% versus 20% for O157), while more were associated with international travel (14% versus 3% for O157). Conclusions: Improved understanding of the epidemiologic features of non-O157 STEC infections can inform food safety and other prevention efforts. To detect both O157 and non-O157 STEC infections, clinical laboratories should routinely and simultaneously test all stool specimens submitted for diagnosis of acute community-acquired diarrhea for O157 STEC and for Shiga toxin and ensure that isolates are sent to a public health laboratory for serotyping and subtyping.

引用

页码：453 / 460

页数：8

共 24 条

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